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EC number: 227-824-5 | CAS number: 5994-61-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Not reported
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
- Justification for data waiving:
- other:
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
- Principles of method if other than guideline:
- Acute inhalation toxicity of test material was determined by exposing test animals for 4 h to test material aerosols. All animals were observed for mortality and clinical signs during the l4-day postexposure period.
- GLP compliance:
- no
- Test type:
- other: Acute inhalation toxicity
- Limit test:
- no
Test material
- Reference substance name:
- N-(carboxymethyl)-N-(phosphonomethyl)glycine
- EC Number:
- 227-824-5
- EC Name:
- N-(carboxymethyl)-N-(phosphonomethyl)glycine
- Cas Number:
- 5994-61-6
- Molecular formula:
- C5H10NO7P
- IUPAC Name:
- 2-[(carboxymethyl)(phosphonomethyl)amino]acetic acid
- Details on test material:
- - Name of test material (as cited in study report): Glyphosate intermediate
- Analytical purity: 97.28 %
- Lot/batch No.: LBIG-12-026
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Not reported
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- TEST ATMOSPHERE
- Particle size distribution: Approximately 50 % of the particles were less than 10 microns in diameter
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): 7.2 microns
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Concentrations:
- 6.1 mg test material/L of air
- No. of animals per sex per dose:
- Five
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 d
- Frequency of clinical observations and weighing: Animals were observed for mortality and clinical signs during the exposure and twice daily during the 14 d postexposure period. Body weights were recorded prior to exposure and on postexposure Days 2, 3, 4, 7 and 14
- Necropsy of survivors performed: Yes
- Other examinations performed: Complete gross necropsy examination - Statistics:
- Not reported
Results and discussion
- Preliminary study:
- Not applicable
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 6.1 mg/L air
- Exp. duration:
- 4 h
- Remarks on result:
- other: No mortality was observed
- Mortality:
- No mortality resulted from the inhalation exposure to 6.1 mg/L of test material.
- Clinical signs:
- other: Nasal discharge and colored material about the eyes, nose and mouth observed in treated animals.
- Body weight:
- Body weights of treated animals were depressed below their pre-exposure weights on postexposure Days 2-4. By Day 3 or 4, all animals were gaining weight at a rate equivalent to controls.
- Gross pathology:
- Red foci on the lung and thymus observed at a greater frequency in the treated group as compared to controls.
- Other findings:
- None
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: EU CLP
- Conclusions:
- Under the test conditions, the inhalation LC50 of test material is considered to > 6.1 mg/L and is not considered to present a significant acute inhalation hazard.
- Executive summary:
A study was conducted to evaluate the inhalation toxicity of test material in Sprague Dawley albino rats.
5 animals/sex were exposed to test material dust aerosol atmosphere at a concentration of 6.1 mg/L of air for 4 h. Animals exposed to air only served as control. Animals were observed for mortality and clinical signs. On postexposure Day 14, all, animals were killed and given a complete gross necropsy examination.
No mortality was observed. Body weights of treated animals were depressed below their pre-exposure weights on postexposure Days 2-4. By Day 3 or 4, all animals were gaining weight at a rate equivalent to controls. Nasal discharge and colored material about the eyes, nose and mouth observed in treated animals. Red foci on the lung and thymus observed at a greater frequency in the treated group as compared to controls.
Under the test conditions, the inhalation LC50 of test material is considered to > 6.1 mg/L and is not considered to present a significant acute inhalation hazard.
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