N-(carboxymethyl)-N-(phosphonomethyl)glycine

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Not reported

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study well documented, meets generally accepted scientific principles, acceptable for assessment

Justification for data waiving:

other:

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1999

Report date:

1999

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The solubility of the test material in water was determined as a function of temperature from 20 to 90 °C. Saturated solutions containing some solid test material were prepared above the target temperature and then cooled to the target temperature, with liquid samples being taken periodically thereafter for determination of test material content.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

N-(carboxymethyl)-N-(phosphonomethyl)glycine

EC Number:

227-824-5

EC Name:

N-(carboxymethyl)-N-(phosphonomethyl)glycine

Cas Number:

5994-61-6

Molecular formula:

C5H10NO7P

IUPAC Name:

2-[(carboxymethyl)(phosphonomethyl)amino]acetic acid

Details on test material:

- Name of test material: Glyphosate intermediate

Results and discussion

Water solubility

Water solubility 1

Water solubility:

0.6 other: wt % ( at 9 h 14 min)

Temp.:

20 °C

Water solubility 2

Water solubility:

0.82 other: wt % ( at 7 h 58 min)

Temp.:

30 °C

Water solubility 3

Water solubility:

1.07 other: wt % ( at 10 h 5 min)

Temp.:

40 °C

Water solubility 4

Water solubility:

1.36 other: wt % ( at 8 h 50 min)

Temp.:

50 °C

Details on results:

Not reported

Any other information on results incl. tables

Only determination of the solubility of the test material in water as a function of temperature was taken into account in this summary.

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): soluble (1000-10000 mg/L)
Under the test conditions, the solubility of different saturated solutions of the test material in wt % were 0.60 at 9 h 14 min (20 °C), 0.82 at 7 h 58 min (30 °C); 1.07 at 10 h 5 min (40 °C) and 1.36 at 8 h 50 min (50 °C). The test material is considered to be soluble in water at 20 °C (solubility = 6 g/L, i.e., between 1000 - 10000 mg/L).

Executive summary:

A study was performed to determine the solubility of the test material in water as a function of temperature from 20 to 90°C.

Saturated solutions containing solid test material were prepared above the target temperature and then cooled to the target temperature, with liquid samples being taken periodically thereafter for determination of test material content. Measurements of pH and particle size were recorded periodically during the crystallization. The test material slurries were allowed to approach their equilibrium concentrations for 8-10 hour. The solid in each slurry was isolated and compared to the amount of soluble test material determined by analysis to verify this measurement.

Under the test conditions, the solubility of different saturated solutions of the test material in wt % were 0.60 at 9 h 14 min (20 °C), 0.82 at 7 h 58 min (30 °C); 1.07 at 10 h 5 min (40 °C) and 1.36 at 8 h 50 min (50 °C). The test material is considered to be soluble in water at 20 °C (solubility = 6 g/L, i.e., between 1000 - 10000 mg/L).