Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 217-915-8 | CAS number: 2008-39-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Oct 1997 - Dec. 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP - Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- , only one sex is tested
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Dimethylammonium 2,4-dichlorophenoxyacetate
- EC Number:
- 217-915-8
- EC Name:
- Dimethylammonium 2,4-dichlorophenoxyacetate
- Cas Number:
- 2008-39-1
- Molecular formula:
- C8H6Cl2O3.C2H7N
- IUPAC Name:
- dimethylammonium 2,4-dichlorophenoxyacetate
- Details on test material:
- - Name of test material (as cited in study report): Aminopielik 720 SL
- Physical state: light brown solution with characteristic smell
- Analytical purity: 726 g/L of 2,4-D
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Institute of Occupational Medicine, Lodz, Poland
- Age at study initiation: 3 months (mean)
- Weight at study initiation: 190 g (mean)
- Fasting period before study: 20 h
- Housing: plastic metal cage (35 x 30 x 20 cm3), 5 animals of the same sex per cage
- Diet: "Murigran" ad libitum
- Water: ad libitum
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2
- Humidity (%): 40 - 80
- Photoperiod (hrs dark / hrs light): 12 /12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Amount of vehicle (if gavage): 5 ml/kg bw - Doses:
- 507, 659, 857 and 1114 mg/kg bw
- No. of animals per sex per dose:
- 5 (only female animals)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
Clinical examination was carried out every hour on the day of application, afterwards at least twice daily. The mortality and all signs of intoxication
were assessed.
Individual weight was determined shortly before the test substance was administered and on days 7 and 14.
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 764 mg/kg bw
- Based on:
- test mat.
- Mortality:
- After exposure 0, 1, 3 and 5 rats died in the dose groups 507, 659, 857 and 1114 mg/kg bw, respectively. The mortality occurred during the first day (all 3 affected dose groups) and on day 2 and 4 (857 mg/kg bw dose group) after application.
- Clinical signs:
- other: Shortly after application of the test substance (0.5 - 2 hours) rats in all dose groups were less mobile, had unstable equilibrium and weak reactions to external impulses. Animals dosed with 857 mg/kg bw showed this intoxication signs till the fourth day
- Gross pathology:
- In 4 rats (one animal of the dose groups 659 and 857 mg/kg bw respectively and two animals treated with 1114 mg/kg bw) lung hyperemia was observed.
In animals that survived the observation period no gross pathologic changes were found.
Any other information on results incl. tables
Table 1: Acute oral toxicity of Aminopielik 720 SL
Dose mg/kg bw |
Mortality of rats after x hours of intoxication (rat identification number) |
Sum |
||||
3 h |
24 h |
48 h |
72 h |
96 h |
|
|
507 |
- |
- |
- |
- |
- |
0 |
659 |
- |
8 |
- |
- |
- |
1 |
857 |
- |
15 |
11 |
- |
14 |
3 |
1114 |
16 17 |
18 19 20 |
- |
- |
- |
5 |
Table 2: Body weight gain
Dose mg/kg bw |
No of rat |
Day of experiment |
Difference day 14- day 1 |
||
|
|
1 |
7 |
14 |
|
507 |
1 2 3 4 5 |
191 189 206 185 186 |
214 210 223 209 207 |
222 217 241 225 221 |
31 28 35 40 35 |
659 |
6 7 8 9 10 |
179 182 185 180 179 |
205 205 - 224 207 |
220 216 - 244 213 |
41 34 - 64 34 |
857 |
11 12 13 14 15 |
206 195 192 200 221 |
- 208 216 - - |
- 232 234 - - |
- 37 42 - - |
1114 |
16 17 18 19 20 |
186 187 188 189 182 |
- - - - - |
- - - - - |
- - - - - |
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.