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EC number: 696-364-9
CAS number: 133779-11-0
The aim of the study
was to determine tissue/organ distribution of14C-Octadecyl
diamineafter oral administration in the male rat using quantitative
whole-body autoradiography. Specifically: the rats were given 62.5 or
6.25 mg/kg body weight of the test item by gavage, and were killed 1, 4
and 24 hours after the last administration.
Two daily repeated
applications in the high dose level with "cold" test item followed by
one application of radiolabeled test item on the 3rd day.
Six daily repeated
applications in two dose levels with "cold" test item followed by one
application of radiolabeled test item on the 7th day.
distribution pattern was similar for all animals independent of time
points, doses or dose regimens. The highest tissue concentrations of
radioactivity were registered in the intestinal mucosa, abdominal lymph
nodes, liver, spleen, adrenal cortex, myocardium and brown fat. All
other tissues showed low or very low levels of radioactivity.
The labeled diamine
seemed to be quite slowly absorbed from the gastrointestinal tract. The
blood radioactivity was low and slightly above LOQ for the different
doses and dose regimens. Furthermore, for almost all tissues the highest
concentration of radioactivity was obtained at 24 hours after the
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