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EC number: 696-364-9
CAS number: 133779-11-0
The safety assessment according to Annex 1 does not indicate the need to investigate further the effects on aquatic organisms. Therefore no chronic fish testing is justified.
According to Annex IX, 9.1.6 to the REACH Regulation long-term toxicity
testing with fish shall be proposed only if the CSA indicates the need
to investigate further the effects on aquatic organisms. However, as the
CSA does not indicate the need for further testing of vertebrates
long-term toxicity testing with fish is waived. Waiving is supported by
the low bioaccumulation potential of the substance and the fact that the
acute toxicity data demonstrate that fish are less sensitive to the
linear alkyl diamines compared to daphnia and algae.
For the calculation of the PNECaquatic it is considered unlikely that
fish toxicity will be critical for alkyl-1,3-diaminopropanes. Hence any
additional toxicity testing with fish will not add scientific value to
the ecotoxicity profile of the alkyl-1,3-diaminopropanes other than for
obtaining a lower assessment factor. It is therefore concluded that for
scientific reasons and in accordance to REACH legislation further
testing on fish has to be avoided for reasons of animal welfare.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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