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EC number: 696-364-9
CAS number: 133779-11-0
The 21d EC50 daphnia magna of 566 µg/L (parental mortality, OECD 211, river water test, reliability 1) is used as key value for the acute toxicity to aquatic invertebrates in the chemical safety assessment.
Acute toxicity tests are available for daphnia magna for various
alkyl-1,3 -diamines with C12 -18 chains (reliability 2 and 3).
The lowest 48h EC50 for Daphnia magna of 6.2 ug/L was determined in a
test with the glassware presoaked overnight. At that time it was thought
that this approach would compensate the loss of the substance to
glassware. Later on the use of LC-MS/MS techniques to quantify the
substance down to 0.5 µg/L, showed that presaturation is leading to test
concentrations which are higher than nominal. Therefore this value has
not been selected as key value.
The acute toxicity tests were conducted in a period when no reliable
specific method of analyses was available. The concentrations were
therefore not analytically verified. The substance is known for its poor
water solubility and the strong tendency to adsorb onto the walls of
test vessels. Therefore it was decided to perform a number of higher
tier chronic invertebrate studies with analytical monitoring of the test
concentrations. These higher tier tests were performed in river water to
allow a PECaquatic,bulk/PNECaquatic,bulk approach for the environmental
risk assessment. The long term 21d EC50 for parental mortality
determined in the OECD211 test with river water (reliability 1) was used
as the key value for acute toxicity for daphnia in the chemical safety
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