Registration Dossier
Registration Dossier
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EC number: 947-818-2 | CAS number: -
Endpoint summary
Administrative data
Description of key information
A single skin sensitization study was conducted on the test article. The result was:
Local lymph node assay (LLNA) (OECD 429): Category 1B Sensitizer
The skin sensitization potential of the test article was evaluated in a local lymph node assay per OECD 429 and GLP. In the pre-screen test no significant irritation was seen, but hunched posture was observed in both animals treated with 100% test article. Therefore, test article concentrations of 10, 25, and 50% were tested in the main test (vehicle: acetone:olive oil 4:1), along with a concurrent positive control (25% alpha-hexylcinnamaldehyde in acetone:olive oil). The stimulation indices of the test article at the three concentrations were 0.8, 2.2, and 3.3, and the EC3 was determined to be 43.2%. The stimulation index of the concurrent positive control was 6.5. The results of the study (EC3 = 43.2%) indicate that the test article is a Category 1B skin sensitizer according to GHS.
Key value for chemical safety assessment
Justification for classification or non-classification
Based on the results of the study, the test substance is classified as a Category 1B sensitizer according to GHS.
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