Reactionmass of dodecan-2-yl prop-2-enoate and dodecan-3-yl prop-2-enoate and dodecan-4-yl prop-2-enoate

Hydrolysis

Description of key information

MTDID 44430 seems lost quickly in water at various pH and temperature conditions. The half life were in the range of 0.6~11.9 day.

Additional information

Hydrolysis study for MTDID 44430 was performed according to OECD Guidelines No.111:Hydrolysis as a function of pH. 

MTDID is a mixture of isomers. Two main isomers, 3-dodecyl acrylate and 2-dodecyl acrylate were sampled and analyzed throughout the hydrolysis study.

A tier 1 study was conducted at 2 mg/L of MTDID 44430 at pH 4, 7, 9 and 50±0.5˚C in dark for 5 days under static conditions. At the end of day 5, the measured concentrations for both isomers were < LOD for all pH 4, 7 and 9, suggesting the half- lives were less than 5 days at 50 °C and pH 4, 7, and 9.

A tier 2 definitive study was conducted at 2 mg/L of MTDID 44430 at pH 4, 7 and 9 buffer solution and incubated in constant temperature of 15±0.5˚C, 25±0.5˚C and 50±0.5˚C in dark for 30 days. Sample were pulled and analyzed on day 0, 2, 3, 4, 5, 6, 7 and 30. The test item seems to be lost quickly in water at various pH conditions. The half-lives were in the range of 0.6 -11.9 days, with 95% confidence intervals of 0.4 - 28.1 day. The half-lives of test item appear to be independent of pH and temperature conditions. At the end of day 30, the hydrolysis product 2-dodecanol was analyzed, but can only account for about 10% of initial content of 2-dodecyl acrylate.

This is a guideline study conducted under GLP. However, there is a large variance in measured sample concentrations, especially in tier 2 time 0 concentrations. The large analytical variance also resulted in inconsistent time elapsed to be used in rate constant and half life calculation, thus resulted in large variation in half lives. Therefore, this study is considered reliable with restriction.