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EC number: 244-168-5
CAS number: 21041-95-2
A study was conducted to evaluate the
teratogenic effects of the test material in SD rats.
Sperm-positive female Sprague-Dawley rats
were exposed to 0, 0.05, 0.5, or 2 mg/m3 cadmium oxide 6 h/d, 7 d/wk,
from gestation Day 4 through 19.
Maternal toxicity was observed in
Sprague-Dawley rats exposed to 2 mg/m3 cadmium oxide and included body
weights lower than those of the controls and clinical signs of toxicity
(dyspnea and hypoactivity). There was no evidence of embryolethality in
rats at any exposure level. However, in rats exposed to 2 mg/m 3,
developmental toxicity was evidenced by lower fetal weights and a
significant increase in the incidence of reduced skeletal ossifications.
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