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EC number: 244-168-5
CAS number: 21041-95-2
Histopathology incidence and severity
Histio-cytic cell granu-lomas
A repeated dose inhalation exposure study
was conducted in female Wistar rats to determine the effects of the test
material on lungs.
Female Wistar rats were exposed to
concentrations of 25, 50 and 100 μg Cd/m³ (as cadmium oxide), continuous
for 90 d in the 25 and 50 μg Cd/m3 groups, and for 63 d in the last
group (MMAD: 0.19 μm, standard deviation: 1.5).
No clinical signs were reported. A marked
increase of lung weight was found together with no signs of oedema.
Histologically, there were cell proliferations of the bronchi,
bronchioli and alveoli in all exposed animals, indicating hyperplasia of
the lungs. Additionally, histiocytic cell granulomas occurred and
emphysematic areas were detected. There was an impairment of gas
exchange in the high exposed group. Pulmonary changes did preceed the
renal damage (assessed by protein and alkaline phosphatase excretion,
histological examination of the kidneys).
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