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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from handbook

Data source

Reference
Reference Type:
review article or handbook
Title:
TOXICITY CHART FOR THE TEST CHEMICAL
Author:
Jim Smith and Lily Hong-Shum
Year:
2003
Bibliographic source:
Food Additives Data Book,1st edition,2003

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Acute oral toxicity study of the test chemical in rats
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Iron(II) fumarate
EC Number:
205-447-7
EC Name:
Iron(II) fumarate
Cas Number:
141-01-5
Molecular formula:
C4H4O4.Fe
IUPAC Name:
iron(II) fumarate
Test material form:
solid: particulate/powder
Details on test material:
- Name of test material (as cited in study report): Ferrous fumarate
- Molecular formula: C4H4O4.Fe
- Molecular weight : 169.901 g/mol
- Smiles notation : [Fe+2].[O-]C(\C=C\C(=O)[O-])=O
- InChl : 1S/C4H4O4.Fe/c5-3(6)1-2-4(7)8;/h1-2H,(H,5,6)(H,7,8);/q;+2/p-2/b2-1+;
- Substance type:Organic
- Physical state:Solid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
3850 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 850 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50 % mortality observed
Mortality:
50 % mortality was observed in treated rats
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
LD50 was considered to be 3850 mg/kgbw when rat were treated with the test chemical orally.
Executive summary:

In an acute oral toxicity study,rats were dosed with the test chemical orally. 50 % mortality was observed in treated rats at 3850 mg/kg bw. Therefore,LD50 was considered to be 3850 mg/kgbw when rat were treated with the test chemical orally.