Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-447-7 | CAS number: 141-01-5
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to microorganisms, other
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Experimental data of read across chemicals
- Justification for type of information:
- Data is from handbook or collection of data
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: Refer below principle
- Principles of method if other than guideline:
- WoE was prepared from two studies to determine the effect of test chemical on the growth of Pseudomonas putida.
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Pseudomonas putida
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 6 h
- Remarks on exposure duration:
- 16 hours of exposure was provided in WoE 3
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 6 h
- Dose descriptor:
- EC10
- Effect conc.:
- 23 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: WoE 2
- Key result
- Duration:
- 16 h
- Dose descriptor:
- EC10
- Effect conc.:
- 1 190 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: WoE 3
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Based on the growth rate inhibition of Pseudomonas putida due to the test chemical exposure for 6 hours and 16 hours, the EC10 value was determined to be ranges from 23 mg/l to 1190 mg/l.
- Executive summary:
Principle of this study was to determine the effect of test chemical on the growth of Pseudomonas putida. Test chemical exposed for 6 hours with
Pseudomonas putida. Based on the growth rate inhibition of Pseudomonas putida due to the test chemical exposure for 6 hours, the EC10 value was determined to be 23 mg/l.
Principle of this study was to determine the effect of test chemical on the growth of Pseudomonas putida. Test chemical exposed for 16 hours with
Pseudomonas putida. Based on the growth rate inhibition of Pseudomonas putida due to the test chemical exposure for 6 hours, the EC10 value was determined to be 1190 mg/l.
Reference
Description of key information
Based on the above studies, growth rate inhibition of Pseudomonas putida due to the test chemical exposure for 6 hours and 16 hours, the EC10 value was determined to be ranges from 23 mg/l to 1190 mg/l.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 23 mg/L
Additional information
Summarized result from the various experimental sources for the determination of effect of test chemical and structurally and functionally similar read across chemicals on the growth of microorganisms are as mentioned below:
Principle of this study was to determine the effect of test chemical on the growth of Pseudomonas putida. Test chemical exposed for 6 hours with Pseudomonas putida. Based on the growth rate inhibition of Pseudomonas putida due to the test chemical exposure for 6 hours, the EC10 value was determined to be 23 mg/l.
Above study further supported by the second study from handbook. Principle of this study was to determine the effect of test chemical on the growth of Pseudomonas putida. Test chemical exposed for 16 hours with Pseudomonas putida. Based on the growth rate inhibition of Pseudomonas putida due to the test chemical exposure for 6 hours, the EC10 value was determined to be 1190 mg/l.
Based on the above studies, growth rate inhibition of Pseudomonas putida due to the test chemical exposure for 6 hours and 16 hours, the EC10 value was determined to be ranges from 23 mg/l to 1190 mg/l.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
