Registration Dossier
Registration Dossier
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EC number: 248-440-4 | CAS number: 27394-99-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Federal Register 38, No. 187, Para.1500.41, S. 27019, 27.09.73
- Principles of method if other than guideline:
- Test method according to Federal Register 38, No. 187, Para.1500.41, S. 27019, 27.09.73 (Draize Test).
- GLP compliance:
- no
Test material
- Reference substance name:
- N-(1-cyanoethyl)formamide
- EC Number:
- 248-440-4
- EC Name:
- N-(1-cyanoethyl)formamide
- Cas Number:
- 27394-99-6
- Molecular formula:
- C4H6N2O
- IUPAC Name:
- N-(1-cyanoethyl)formamide
- Details on test material:
- N-Formylalaninnitril (purity 98%)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- no data
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of the same animals
- Amount / concentration applied:
- undiluted
- Duration of treatment / exposure:
- 24 h
- Observation period:
- 8 days
- Number of animals:
- 6
- Details on study design:
- no data
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24h-48h-72h
- Score:
- 0.06
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24h-48h-72h
- Score:
- 0.55
- Reversibility:
- fully reversible within: 8 days
Any other information on results incl. tables
Scarified skin:
After 24 h, light to severe erythema and slight oedema were observed, that were reversible after 8 days. Scaling was observed.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- Classification: not irritating
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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