Registration Dossier
Registration Dossier
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EC number: 248-440-4 | CAS number: 27394-99-6
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- BASF-Test (Inhalation Hazard Test): according to: H.F.Smyth et al.: Am. Ind. Hyg. Ass. J. 23, 95-107 (1962): 12 rats (6 male and 6 female) were exposed for 7 hours to an atmosphere that has been saturated at 20 degrees centigrade with the volatile part of the compound. The animals were then observed for 14 days.
- GLP compliance:
- no
- Test type:
- other: Inhalation hazard test
Test material
- Reference substance name:
- N-(1-cyanoethyl)formamide
- EC Number:
- 248-440-4
- EC Name:
- N-(1-cyanoethyl)formamide
- Cas Number:
- 27394-99-6
- Molecular formula:
- C4H6N2O
- IUPAC Name:
- N-(1-cyanoethyl)formamide
- Details on test material:
- N-Formylalaninnitril (purity 98%)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: water
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Temperature in air chamber: 20 °C - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 7 h
- Concentrations:
- 0.21 mg/l; 52,5 ppm
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- > 210 mg/m³ air
- Exp. duration:
- 7 h
- Remarks on result:
- other: no mortality occured
- Mortality:
- no mortality
- Clinical signs:
- other: During the experiment the animals showed attempt to escape, slight nose discharge and dyspnoea. One animal showed tremulous convulsions. After 4 hours, all animals were without symptoms.
- Body weight:
- no data
- Gross pathology:
- Nothing abnormal detected
Any other information on results incl. tables
No mortality occured. During the experiment the animals showed attempt to escape, slight nose discharge and dyspnoea. One animal showed tremulous convulsions. After 4 hours, all animals were without symptoms.
The animals were sacrified 14 days after application. During pathology nothing abnormal was detected.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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