Registration Dossier

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
DPIM : HMY500
Author:
Richard J. Lewis, Sr.
Year:
2007
Bibliographic source:
SAX (Sax's Handbook of Dangerous Industrial Materials):-28ZPAK  Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia.:  , 1972, 181.
Reference Type:
review article or handbook
Title:
RTECS Number : OY2357500
Author:
RTECS handbook
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances):-85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1052,1986

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
Standard Draize test
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
not specified
Controls:
not specified
Duration of treatment / exposure:
24H

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 24H
Max. score:
100
Remarks on result:
other: Dose:100 mg/24H ; Moderate irritation

Applicant's summary and conclusion

Interpretation of results:
moderately irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The substance is moderately irritating to rabbit eye.
Executive summary:

The 24 h study of the target chemical, 3-amino-2-hydroxy-5-nitrobenzenesulphonic acid, on rabbits indicate that the substance is moderately irritant to eyes and so will be considered for classification in Eye irritation category 2.