Registration Dossier

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This substance is a structural analog (read across) to the target chemical, 3-amino-2-hydroxy-5-nitrobenzenesulphonic acid and have more than 92.6 % similarity.

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
DPIM: AKI250
Author:
Richard J. Lewis, Sr.
Year:
2007
Bibliographic source:
SAX (Sax's Handbook of Dangerous Industrial Materials); Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia.:1972, 182.
Reference Type:
review article or handbook
Title:
RTECS Number: DB4900000
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances); 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1053,1986

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
Standard Draize test
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: 3-amino-4-hydroxy-5-nitrobenzenesulphonic acid
- Molecular formula: C6H6N2O6S
- Molecular weight: 234.19
- Substance type: organic

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
500 mg/24H
Duration of treatment / exposure:
24H

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 24h
Max. score:
500
Reversibility:
no data
Remarks on result:
other: Mildly irritating

Applicant's summary and conclusion

Interpretation of results:
slightly irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
3-amino-4-hydroxy-5-nitrobenzenesulphonic acid is found to be slightly irritating to rabbit's skin at 500 mg/24H of concentration.
Executive summary:

3-amino-4-hydroxy-5-nitrobenzenesulphonic acid is found to be slightly irritating to rabbit's skin at 500 mg/24H of concentration. Since this substance is a structural analog (read across) to the target chemical, 3-amino-2-hydroxy-5-nitrobenzenesulphonic acid, having more than 92.6 % similarity and thus the toxicity effect can be considered for the target substance as well. Thus it can be infered that 3-amino-2-hydroxy-5-nitro benzene sulphonic acid is skin irritant in category 2.