Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
17.01.2013 - 31.01.2013
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2012
Report Date:
2013

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: shake-flask method
Principles of method if other than guideline:
Determination of ratio of concentrations of a compound in the two phases of a mixture of Octanol-Water at equilibrium
GLP compliance:
no
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: Amorphous
Details on test material:
- Name of test material : 3-amino-2hydroxy-5-nitrobenzenesulphonic acid
- Substance type: Organic
- Physical state: Solid

Results and discussion

Partition coefficient
Type:
Pow
Partition coefficient:
0.38
Temp.:
22 °C
pH:
2.67
Details on results:
Converting the above Pow value into its Log value, the Log Pow of 3-amino-2hydroxy-5-nitrobenzene sulphonic acid is -0.04202 at temperature 22 deg C and pH of 2.67

Applicant's summary and conclusion

Conclusions:
The experimental value of octanol water partition co-efficient (log Pow) of of 3-amino-2-hydroxy-5-nitrobenzene sulphonic acid by Shake flask method was found to be -0.04202 at temperature 22 degC and pH of 2.67.This value indicates that 3-amino-2hydroxy-5-nitrobenzene sulphonic acid is hydrophilic in nature.
Executive summary:

The experimental value of octanol water partition co-efficient (log Pow) of of 3-amino-2-hydroxy-5-nitrobenzene sulphonic acid by Shake flask method was found to be -0.04202 at temperature 22 degC and pH of 2.67.This value indicates that 3-amino-2hydroxy-5-nitrobenzene sulphonic acid is hydrophilic in nature.