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EC number: 939-605-8
CAS number: 68152-93-2
Reproductive indices (fertility index, gestation index and birth index) and offspring viability indices (live birth index, viability index) were determined. At 10000ppm there was a slight increase in the number of nights to a positive mating sign, and in the duration of gestation. Additionally, the mean number of implants per pregnancy was slightly decreased with a subsequent reduction in litter size and litter weight. There were no obvious effects of treatment on mating performance, duration of gestation, litter size and pup weight in animals treated at 1000 and 3000 ppm.
This is a repeat dose toxicity study conducted according to guideline protocol with the objective of providing initial information on possible effects on reproduction and/or development in rats. Rosin fumarated was administered in the diet to rats at concentrations of 0, 1000ppm (males 72 -89 mg/kg bw/d; females 79 -108 mg/kg bw/d), 3000 ppm (males 221 -288 mg/kg bw/d; females 196 -292 mg/kg bw/d), and 10000 ppm (males 651 -889 mg/kg bw/d; females 449 -995 mg/kg bw/d). The males were treated for 2 weeks prior to mating, through until necropsy after 4 weeks of treatment. The females were treated for 2 weeks prior to mating, then through mating, gestation and until termination on at least Day 4 of lactation. Under the conditions of this study, parental toxicity was exhibited at levels of 3000 and 10000 ppm, with a decrease in mean body weight at both doses and sexes, an increase in total bilirubin in both sexes at 10000 ppm and decrease in adrenal gland weight in females at 10000 ppm, but there were no clear effects of toxicity at 1000 ppm. Therefore, the parental NOEL was considered to be 1000 ppm (males 72 -97 mg/kg bw/d; females 79 -108 mg/kg bw/d). For reproductive parameters the NOEL was considered to be 3000 ppm (females: 196 -268 mg/kg bw/d).
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