Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 939-605-8
CAS number: 68152-93-2
Reproductive indices (fertility index, gestation index and birth index) and offspring viability indices (live birth index, viability index) were determined. At 10000ppm there was a slight increase in the number of nights to a positive mating sign, and in the duration of gestation. Additionally, the mean number of implants per pregnancy was slightly decreased with a subsequent reduction in litter size and litter weight. There were no obvious effects of treatment on mating performance, duration of gestation, litter size and pup weight in animals treated at 1000 and 3000 ppm.
This is a repeat dose toxicity study conducted according to guideline protocol with the objective of providing initial information on possible effects on reproduction and/or development in rats. Rosin fumarated was administered in the diet to rats at concentrations of 0, 1000ppm (males 72 -89 mg/kg bw/d; females 79 -108 mg/kg bw/d), 3000 ppm (males 221 -288 mg/kg bw/d; females 196 -292 mg/kg bw/d), and 10000 ppm (males 651 -889 mg/kg bw/d; females 449 -995 mg/kg bw/d). The males were treated for 2 weeks prior to mating, through until necropsy after 4 weeks of treatment. The females were treated for 2 weeks prior to mating, then through mating, gestation and until termination on at least Day 4 of lactation. Under the conditions of this study, parental toxicity was exhibited at levels of 3000 and 10000 ppm, with a decrease in mean body weight at both doses and sexes, an increase in total bilirubin in both sexes at 10000 ppm and decrease in adrenal gland weight in females at 10000 ppm, but there were no clear effects of toxicity at 1000 ppm. Therefore, the parental NOEL was considered to be 1000 ppm (males 72 -97 mg/kg bw/d; females 79 -108 mg/kg bw/d). For reproductive parameters the NOEL was considered to be 3000 ppm (females: 196 -268 mg/kg bw/d).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Deze website maakt gebruik van cookies om het surfen zo aangenaam mogelijk te maken.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again