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EC number: 939-605-8
CAS number: 68152-93-2
Natural fatty acids and their salts are well characterised for metabolic processes. Maleic acid is a natural substance essential in metabolic pathways. Linear fatty acids will be more likely to adsorb if ingesdted, but rosin acids and gums are less likely to be absorbed; either way, this class of materials are used in foods and food additives (eg gums, food thickeners etc) and there is considered no risk of accumulation in the food chain.
Endpoint specific guidance (ECHA, 2008) indicates that absorption of substances following exposure by inhalation, skin contact or ingestion may be predicted based on log Pow and water solubility. Experimentally determined results for substances in this category are as follows:
Fatty acids, tall oil, oligomeric reaction products with maleic anhydride and rosin, calcium magnesium zinc salts
0.4 (pH 5.43)
Resin acids and Rosin acids, maleated, sodium salts (and Tall oil…)
Resin acids and Rosin acids, maleated, calcium salts
2.8 (pH 3.93-4.47)
Rosin, fumarated, reaction product with formaldehyde
3.3 (pH 3.99-4.37)
ECHA (2008) indicates that uptake of substances by the lung and by the gastrointestinal tract is favoured by moderate log P values (between -1 and 4) with micellular solubilisation favoured where log P is >4 and water solubility is low (< 1 mg/l). Data summarised above indicate that the log Pow for Fatty acids, tall oil, oligomeric reactions products with maleic anhydride and rosin, calcium magnesium zinc salts and Rosin, fumarated, reaction product with formaldehyde is less than 4 suggesting that some uptake after exposure via these routes may be possible. For the other category members, variations in the magnitude of the log Pow make it hard to draw any conclusion.
Dermal absorption of highly water soluble substance may occur where the log Pow is between 1-4 with log Pow values between 2 and 3 favouring uptake. When log Pow exceeds 4, penetration may be limited by the rate of transfer between the stratum corneum and epidermis although uptake of a substance by the stratum corneum will be high. Uptake of substances where log Pow exceeds 6 will be low (ECHA, 2008). Data summarised above suggest that Fatty acids, tall oil, oligomeric reactions products with maleic anhydride and rosin, calcium magnesium zinc salts and Rosin, fumarated, reaction product with formaldehyde may be absorbed although the extent of uptake is not clear. Variations in the magnitude of the log Pow make it hard to reach any conclusions for the other category members.
No experimental data are available to characterise the toxicokinetic behaviour of substances in this category.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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