Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 939-605-8
CAS number: 68152-93-2
The acute dermal toxicity of Rosin fumarated was evaluated using 5 male and 5 female Sprague Dawley rats. The fur was removed from the dorsal area of the trunk of the animals by clipping and a dose of 2000 mg/kg body weight was applied onto the 10% of the clear skin for 24 hrs. The treated area was covered by a semi-occlusive dressing consisting of a gauze patches hydrophilic, which was held in contact with the skin by means od 50 mm wide hypoallergenic micropore adhesive tape. After 24 hrs exposure, the gauze was removed and the treated area was rinsed with dimethyl sulfoxide.
The animals were observed for 24 hrs. Signs of toxicity and behavioural effect were recorded daily, while weight gain was recorded at D0, D2, D7 and D14. No mortality occurred during the study. The results showed no signs of toxicity related to the administration of the test material. Erythema and yellow coloration of the treated area were noted from 24 hrs post-dose in all animals and were totally reversible on D8. No change in body weight was recorded and macroscopic examination did not show any treatment related changes.
In conclusion, the LD50 of Rosin fumarated is higher than 2000 mg/kg body weight.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Deze website maakt gebruik van cookies om het surfen zo aangenaam mogelijk te maken.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again