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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: A scientific review (peer reviewed). No data on GLP.

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1975

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 406 (Skin Sensitisation)
Principles of method if other than guideline:
The maximization test was carried out on 25 volunteers; the material was tested at a concentration of 10% in petrolatum. The author of the study report is Dr. Klingman - coauthor of the maximization test adopted by OECD.
GLP compliance:
not specified
Type of study:
other: maximitization test

Test material

Reference
Name:
Unnamed
Type:
Constituent

In vivo test system

Test animals

Species:
human
Sex:
not specified

Study design: in vivo (non-LLNA)

Induction
Concentration / amount:
10% in petroleum
Challenge
Concentration / amount:
10% in petroleum
No. of animals per dose:
25 volunteers

Results and discussion

Any other information on results incl. tables

The substance produced no sensitization reactions.

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information
Conclusions:
The substance was no sensitizing.
Executive summary:

The maximization test of Isobornyl acetate was carried out on 25 volunteers; the material was tested at a concentration of 10% in petrolatum. The substance produced no sensitization reactions.