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Diss Factsheets
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EC number: 907-658-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No GLP compliance and no data on guidelines requirements.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
- Principles of method if other than guideline:
- Exposure of rats to 44 different odour substances and examination of olfactory bulbs.
- GLP compliance:
- no
- Type of method:
- in vivo
- Endpoint addressed:
- not applicable
Test material
- Reference substance name:
- Exo-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl acetate
- EC Number:
- 204-727-6
- EC Name:
- Exo-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl acetate
- Cas Number:
- 125-12-2
- Molecular formula:
- C12H20O2
- IUPAC Name:
- (1S,2S,4S) 1,7,7-trimethylbicyclo[2.2.1]hept-2-yl acetate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 2 weeks
- Weight at study initiation: 28-39 g
- Housing: cylindrical cages, with closed tops
ENVIRONMENTAL CONDITIONS
- Air changes: 0,6 litre X sec-1
Administration / exposure
- Route of administration:
- inhalation
- Vehicle:
- unchanged (no vehicle)
- Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- Each substance was introduced into the air stream from a glass bottle, the content of which was weighed before and after the experiments to measure the concentration of substance in the stream.
- Duration of treatment / exposure:
- For IBA: 4 weeks and 8 weeks
- Frequency of treatment:
- Continous
Doses / concentrations
- Remarks:
- Doses / Concentrations:
7.9 E(-9) M
Basis:
analytical conc.
- No. of animals per sex per dose:
- For IBA: 3 animals
- Control animals:
- yes
Results and discussion
Any other information on results incl. tables
Administration of IBA 7.9 E-9 M (1.551 mg/m3):
after 4 weeks: mean weight of animals at sacrifice: 107 g
after 8 weeks: mean weight of animals at sacrifice: 220 g
Applicant's summary and conclusion
- Conclusions:
- For IBA was observed a specific pattern of mitral cell degeneration in the olfactory bulb: a heavy 'degeneration' of granule cells in the ventral area of the bulb.
- Executive summary:
Rats have been exposed to a variety of constant odorous environments from 2 weeks of age for periods from 1 to 12 weeks. They have been compared with control litter-mates exposed to a non-odorised milieu for the same periods. For each of 44 different odours a specific pattern of mitral cell degeneration was observed in the olfactory bulb; the pattern and extent of this 'selective degeneration' did not appear to be correlated with the concentration of the odorant. The pattern of degeneration in coronal sections was maintained through the antero-posterior extent of the bulb in most cases. These results suggest a topological representation of different odours in the olfactory bulb. The implications of selective degeneration in the study of odour-quality discrimination are discussed.
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