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EC number: 217-886-1 | CAS number: 1999-85-5
The substance showed no effect on intact skin after exposure for 4 hours, moistened and semi-occlusive, according to OECD 405. This is confirmed by a study in which abraded and intact skin was exposed to the subsatnce for 24 hours, the substance was also moistened in this case but there is no information on how the substance was kept in contact with the skin.
A animals were exposed to 0.1 grams test substance on their eye in 2 goups. In one group the eyes were washed 30 seconds after exposure. Slight effects were observed in both groups. These findings are confirmed by another eye irritation/corrosion study.
Four healthy Japanese white rabbits were taken for the test. 0.5g test substance was applied to an area of shaved skin on left of back of four healthy rabbits and the application site was covered with a semi-occlusive dressing for four hours. Following exposure, dermal irritation was evaluated by the method in the "The Guidelines for the Testing of Chemicals" at 24, 48 and 72h after removal of the dressing. No erythema was observed on the treated skin area of any rabbit. There was no erythema on the control area of the rabbits. The average score of skin responses was 0. According to "The Guidelines for the Hazard Evaluation of New Chemical Substances", a,a,a',a'-tetramethyl-m-xylene-a,a'-diol belongs to non-irritation for rabbits' skin.
Four healthy Japanese white rabbits were taken for the test. An eye irritation test was conducted with rabbits to determine the potential ability to produce irritation and corrosion of test substance. O.lg test substance was put into the left eye of four healthy rabbits. The right eye was treated with 0.1 ml normal saline served as control. Eye irritation was evaluated by the methods in "The Guidelines for the Testing of Chemicals" after exposure. No eye reactions occurred after exposure until the 72 h. The Index of Acute Ocular Irritation (I.A.O.I.) was "0". According to "The Guidelines for the Hazard Evaluation of New Chemical Substances", a,a,a',a'-tetramethyl-m-xylene-a,a'-diol belongs to non-irritation for rabbits' eyes.
Justification for selection of skin irritation / corrosion endpoint:
The 2012 was selected as the key study and is valid with restrictions due to some deficencies (see endpoint study record). However, it was apparentlyconducted in accordance with current guidelines and includes a QA certification.
An older study is available, which deviates from the current guideline, and has limited details but supports the conclusion of the more current study.
Justification for selection of eye irritation endpoint:
The 2012 was selected as the key study and is valid with restrictions due to some deficencies (see endpoint study record). However, it was conducted in accordance with current guidelines and includes a QA certification statement.
Based on the available information the substance is not classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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