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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
March 2011
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Well conducted study according to EU draft and ISO guidelines, under Internal Management System and certificate of analysis included in the report.
Qualifier:
according to
Guideline:
other: ISO2591-1, Test sieving – Part 1: Methods using test sieves of woven wire cloth and perforated metal plate, December 1988
Deviations:
no
Qualifier:
according to
Guideline:
other: ISO 3310-1, Test sieves – Technical requirements and testing – Part 1: Test sieves of metal wire cloth, July 1990
Deviations:
no
Qualifier:
according to
Guideline:
other: Intern Akzo Nobel SMA 721.02, Determination of the particle size distribution of powders and granular products
Deviations:
no
Qualifier:
according to
Guideline:
other: Intern AkzoNobel SMA743.02, Distribution of powders and granulated products in representative portions, August 1993
Deviations:
no
Qualifier:
according to
Guideline:
other: DRAFT EUR 20268 EN Guidance document on the determination of particle size distribution, fiber length and diameter distribution of chemical substances, 2002
Deviations:
no
GLP compliance:
no
Remarks:
Internal Management System
Type of method:
sieving
Type of distribution:
other: passing 100 µm sieve
Percentile:
D50
Mean:
< 100 µm
Remarks on result:
other: No particles pass the sieve. (migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.)

Light microcopic examination

The picture in the report shows that a small amount of particles < 100 µm is present. The shape of these fines is non-fibrous. See attachment.

Sieving

 

Fraction

Pot 2

Pot 3

[g]

[%]

[g]

[%]

< 100µm

0.00

0.0

0.00

0.0

> 100µm

100.49

100.0

105.50

100.0

 

It is shown that no particles pass the 100 µm sieve. The presence of water makes the product more sticky and the (fine) particles agglomerate. Consequently no PSD(Particle Size Distribution)  has to be determined.

Conclusions:
Light microscopic examination revealed that the α,α,α',α'-tetramethyl-m-xylene-α,α-diol contains a small amount of particles < 100 µm. The shape of these fines is non-fibrous.
No particles pass the 100 µm sieve. The presence of water makes the product more sticky and the (fine) particles agglomerate. As a result α,α,α',α'-tetramethyl-m-xylene-α,α-diol is not dusty.
There is no inhalation risk related to α,α,α',α'-tetramethyl-m-xylene-α,α-diol.
Executive summary:

The granulometry of α,α,α',α'-tetramethyl-m-xylene-α,α-diol was determined in accordance with European Chemicals Agency (ECHA), Guidance on information requirements and chemical safety assessment, Chapter R.7a, Endpoint specific guidance, May 2008.

Description of key information

There is no inhalation risk related to α,α,α',α'-tetramethyl-m-xylene-α,α-diol. Light microscopic examination revealed that the α,α,α',α'-tetramethyl-m-xylene-α,α-diol contains a small amount of particles < 100 µm. The shape of these fines is non-fibrous.

No particles pass the 100 µm sieve. The presence of water makes the product more sticky and the (fine) particles agglomerate. As a result α,α,α',α'-tetramethyl-m-xylene-α,α-diol is not dusty.

Additional information

The particle size distribution of the sample analysed in China of α,α,α',α'-tetramethyl-m-xylene-α,α'-diol is different than the standard sample analysed in The Netherlands by Altena.The data for granulometry are dependent on the type, production and pretreatment of the sample.