Registration Dossier
Registration Dossier
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EC number: 218-491-7 | CAS number: 2163-00-0
Endpoint summary
Administrative data
Description of key information
In a skin irritation study (BASF.1963), the test item is irritating to skin. In a eye irritation study (BASF.1963), 1,6-dichlorohexane is not irritating to eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
-skin irritation: In a key skin irritation study (BASF.1963) two Vienna White rabbits were treated once with 1,6-dichlorohexane (concentration: 2 mL) via occlusive dermal exposure for 20 h and observed irritation effects for 8 days. A 24 h erythema score of 3 and an average edema score of 2 were deduced (average all animals). The skin reactions were not reversible within 8 d. Thus, the substance is classified as skin irritating.
-eye irritation: In a key eye irritation study (BASF.1963) two Vienna White rabbits were applied to conjunctival sac of eyelid with 1,6-dichlorohexane for 24 h and observed irritation effects for 8 days. An average overall irritation score of 0 were deduced (average all animals). Thus, the substance is not irritating to the eyes.
Justification for selection of skin irritation / corrosion endpoint:
Only one key study.
Justification for selection of eye irritation endpoint:
Only one key study.
Effects on skin irritation/corrosion: irritating
Justification for classification or non-classification
Based on the results for skin irritation study, the substance should be classified and labelled as Category 2: irritating (H315: Causes skin irritation) according to Regulation (EC) No 1272/2008 and as Xi; R38 (Irritating to skin) according to Directive 67/548/EEC.
The substance was classified and labelled as Category 2 according to OECD GHS.
Based on the results for eye irritation study, the substance was not classified and labelled according to Regulation (EC) No 1272/2008 and Directive 67/548/EEC.
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