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EC number: 223-054-9 | CAS number: 3710-30-3
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
LC/EC50 (48 h) = 0.91 - 2.15 mg/L based on QSAR-calculations
Key value for chemical safety assessment
Additional information
An expert statement available for a daphnid immobilization test describes the impossibility of testing of 1,7 -octadiene in the aquatic environment due to technical reasons. As the test item is highly volatile a loss of several mg of the substance was observed in the experiment, even during weighing. Due to these properties, it was not possible to keep the concentrations of the test item within nominal ranges in the test beakers at test start (no concentration measurable at test start). Even the use of stabilisers and the use of closed vessel beakers showed no significant enhancement of the recoveries (2011-0104-DGO). According to the expert statement, the laboratory concluded that it is not possible to assess the toxicity of 1,7 -octadiene on daphnids. The statement further mentioned that the appearance of the test substance in water is very unlikely and the daphnids will not be exposed to nominal concentrations of the test item.
Nevertheless, to further evaluation
of the short-term toxicological profile of the substance
QSAR-calculations were performed. The resulting LC50/EC50-values of the
QSAR-calculations using different models were summarized in the
following table:
LC50/EC50 (48 h) [mg/L] |
Species |
QSAR-tool |
1.13 |
Daphnia sp. |
EPIsuite 4.10 |
0.98 |
Daphnia magna |
OECD Toolbox |
2.15 |
Daphnia magna |
ChemProp / von der Ohe et al. |
0.91 |
Daphnia magna |
ChemProp / Verhaar et al. |
The calculated LC50/EC50-values are within the range of 0.91 – 2.15 mg/L for daphnids, taking into account a test duration of 48 h.
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