Registration Dossier
Registration Dossier
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EC number: 231-106-7 | CAS number: 7439-97-6
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- other: review article
- Adequacy of study:
- supporting study
- Study period:
- no data available
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Information available from abstract.
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Metallic mercury (Hg) - The biological affects of long-time low to moderate exposures.
- Author:
- Efskind, J.
- Year:
- 2 009
- Bibliographic source:
- Euro Chlor Science Dossier 13
- Reference Type:
- publication
- Title:
- Mercury hygiene practices.
- Author:
- Steffek, A.J.; et al.
- Year:
- 1 987
- Bibliographic source:
- CDA J. Sept: 15(9): 24-9
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Mercury
- EC Number:
- 231-106-7
- EC Name:
- Mercury
- Cas Number:
- 7439-97-6
- Molecular formula:
- Hg
- IUPAC Name:
- mercury
- Details on test material:
- - Name of test material (as cited in study report): metallic mercury
- Molecular formula (if other than submission substance): Hg
No further details are given.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- air
- Details on exposure:
- no data
- Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- no data
- Details on mating procedure:
- No details are reported.
- Duration of treatment / exposure:
- no data
- Frequency of treatment:
- no data
- Duration of test:
- no details: acute and chronic exposure
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
50 μg/m³ mercury vapour
Basis:
nominal conc.
- Remarks:
- Doses / Concentrations:
100 μg/m³ mercury vapour
Basis:
nominal conc.
- Remarks:
- Doses / Concentrations:
500 μg/m³ mercury vapour
Basis:
nominal conc.
- Remarks:
- Doses / Concentrations:
1000 μg/m³ mercury vapour
Basis:
nominal conc.
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- No further details are reported.
Examinations
- Maternal examinations:
- No details are reported.
- Ovaries and uterine content:
- The ovaries and uterine content was examined after termination: Yes
Examinations included:
- Gravid uterus weight: No data
- Number of corpora lutea: No data
- Number of implantations: No data
- Number of resorptions: Yes - Fetal examinations:
- - External examinations: Yes: examination of pups for increased incidence of gross malformations
- Soft tissue examinations: No data
- Skeletal examinations: No data
- Head examinations: No data - Statistics:
- no data
- Indices:
- no data
- Historical control data:
- no data
Results and discussion
Results: maternal animals
Maternal developmental toxicity
- Details on maternal toxic effects:
- Maternal toxic effects:no data
Details on maternal toxic effects:
no data
Effect levels (maternal animals)
- Dose descriptor:
- NOAEC
- Remarks on result:
- not determinable
- Remarks:
- no NOAEC identified
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:yes
Details on embryotoxic / teratogenic effects:
In studies of foetal development, no increased incidence of gross malformations was seen in rats after maternal exposure to mercury vapour at 100 μg/m³. However, acute exposure at 500 μg/m³ gave an increased number of resorptions. Chronic exposure at the same level also gave cranial defects. In a teratological study in rats, embryo toxicity and teratogenic effects were not observed at 50 μg/m³, but were evident at 1000 μg/m³ when this was maintained during the entire gestation or organogenesis period
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- In studies of foetal development, no increased incidence of gross malformations was seen in rats after maternal exposure to mercury vapour at 100 μg/m3. However, acute exposure at 500 μg/m3 gave an increased number of resorptions. Chronic exposure at the same level also gave cranial defects. In a teratological study in rats, embryo-toxicity and teratogenic effects were not observed at 50 μg/m3, but were evident at 1000 μg/m3 when this was maintained during the entire gestation or organogenesis period.
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