Registration Dossier
Registration Dossier
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EC number: 231-106-7 | CAS number: 7439-97-6
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Mercury chloride induced single-strand breaks in different rat and mouse fibrioblast cell lines and CHO cells. Only a weak response was obtained with metabolic activation in a forward mutation assay in mouse lymphoma cells. Sister chromatid exchange was observed in human blood cells, but not in CHO cells. Chromosome aberrations were induced in human peripheral lymphocytes and CHO cells. One study with Hg(II) showed that low concentration bind to DNA in a dose-dependent manner.
The in-vivo genotoxic potential of mercury chloride was estimated in a dominant lethal assay in rats, in chromosome aberration tests in bone marrow cells and spermatoginia of mice following oral and i.p. treatment and in bone marrow cells and oocytes Golden hamsters following s.c. injections. Positive results were obtained in the dominant lethal assay, and following oral treatment of rats in the chromosome aberration test. However, no increase in chromosome aberration was observed after i.p. treatment of mice, and only a slight effect was seen in bone marrow cells, but not in oocytes, of hamsters following s.c. administration of mercury chloride.
In conclusion, in-vitro and in-vivo genotoxicity studies showed equivocal results.
Short description of key information:
The mutagenic and genotoxic potential of mercury chloride was evaluated in several in-vitro test with different endpoints, and the results of 4 in-vivo test are described. There is only one study on DNA binding availble for metallic mercury.
Endpoint Conclusion:
Justification for classification or non-classification
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