Registration Dossier
Registration Dossier
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EC number: 416-530-4 | CAS number: 178949-82-1
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- GLP compliance:
- no
- Dissociating properties:
- yes
- No.:
- #1
- pKa:
- ca. 7.5
- Temp.:
- 20 °C
- No.:
- #2
- pKa:
- ca. 4
- Temp.:
- 20 °C
- Conclusions:
- Only two dissociation constants were determined for this material, the third could not be achieved by titrimetric means due to precipitation of the sample.
The pKa of Na3EDDS was found to be 7.5 at approximately 20 °C, the results scatter obtained was ±0.09. The result is slightly higher than that from the literature (6.8 at 25 °C) this may be due to the influence of a small amount of (0.5%w/w) aspartic acid raw material present in the solution and the lower temperature of titration.
The pKa of Na2EDDS was found to be 4.0 at approximately 20 °C, the results scatter obtained was ±0.11, the result agrees well with the literature value of 3.9 at 25 °C.
Reference
Description of key information
Only two dissociation constants were determined for this material, the third could not be achieved by titrimetric means due to precipitation of the sample.
The pKa of Na3EDDS was found to be 7.5 at approximately 20 °C, the results scatter obtained was ±0.09. The result is slightly higher than that from the literature (6.8 at 25 °C) this may be due to the influence of a small amount of (0.5%w/w) aspartic acid raw material present in the solution and the lower temperature of titration.
The pKa of Na2EDDS was found to be 4.0 at approximately 20 °C, the results scatter obtained was ±0.11, the result agrees well with the literature value of 3.9 at 25 °C.
Key value for chemical safety assessment
- pKa at 20°C:
- 7.5
Additional information
Only two dissociation constants were determined for this material, the third could not be achieved by titrimetric means due to precipitation of the sample. The pKa of Na3EDDS was found to be 7.5 at approximately 20 °C, the results scatter obtained was ± 0.09. The result is slightly higher than that from the literature (6.8 at 25 °C) this may be due to the influence of a small amount of (0.5%w/w) aspartic acid raw material present in the solution and the lower temperature of titration. The pKa of Na2EDDS was found to be 4.0 at approximately 20 °C, the results scatter obtained was ± 0.11, the result agrees well with the literature value of 3.9 at 25 °C.
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