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Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Reference
Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Study period:
December 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Qualifier:
according to
Guideline:
OECD Guideline 201 (Alga, Growth Inhibition Test)
Deviations:
no
GLP compliance:
not specified
Test organisms (species):
Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum)
Test type:
static
Water media type:
freshwater
Total exposure duration:
72 h
Duration:
72 h
Dose descriptor:
EC50
Effect conc.:
102.32 mg/L
Nominal / measured:
estimated
Conc. based on:
not specified
Basis for effect:
growth rate

The estimated value for Ethyl Ethoxycarbonylmethyl 2-methylidenepropanedioate after applying the ProtoQSAR model for acute aquatic toxicity in algae was 102.32 mg/L. Furthermore, the compound falls inside the applicability domain of the model.

Conclusions:
PQSAR model for acute aquatic toxicity in algae estimated for Ethyl Ethoxycarbonylmethyl 2-methylidenepropanedioate an acute 72h EC50 to algae of 102.32 mg/L. The prediction, falls inside the applicability domain of the model and is considered reliable. Furthermore, and based on the Globally Harmonized System of Classification and Labelling (CLP/GHS) , the test compound is considerd non-toxic / non-harmful. 102.32mg/L > 100.
Executive summary:

Regulatory purpose: This study was designed to generate estimated in silico (nontesting) data for acute aquatic toxicity in algae for Ethyl Ethoxycarbonylmethyl 2-methylidenepropanedioate to be used in the regulatory framework of REACH. EC50 = 102.32mg/L

On the basis of EC 50 value it is concluded that this test chemical is considered to be not classified according to CLP classification criteria.

Description of key information

The acute aquatic toxicity in algae (EC50; 72 hours) (OECD 201) of Ethyl Ethoxycarbonylmethyl 2-methylidenepropanedioate was estimated using the PQSAR QSAr model. The estimated value was 102.32 mg/L. The prediction, falls inside the applicability domain of the model and is considered reliable. Furthermore, and based on the Globally Harmonized System of Classification and Labelling (CLP/GHS) , the test compound is considerd non-toxic / non-harmful. 102.32mg/L > 100. On the basis of EC 50 value it is concluded that this test chemical is considered to be not classified according to CLP classification criteria.

Key value for chemical safety assessment

EC50 for freshwater algae:
102.32 mg/L

Additional information