Registration Dossier

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
From 26/07/2018 to 02/11/2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
The test material was found to be fully miscible n-octanol and immiscible in water, therefore formal testing was not possible. The partition coefficient was estimated using prediction software (KOWWIN v1.68).
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
GLP compliance:
no
Type of method:
calculation method (fragments)
Partition coefficient type:
octanol-water
Key result
Type:
log Pow
Partition coefficient:
ca. 0.85
Remarks on result:
other: The model does not provide Temp or pH data for the prediction.
Conclusions:
The partition coefficient octanol-water (Log Kow) of the test item was 0.85 (prediction by QSAR model).
Executive summary:

The test material was found to be fully miscible n-octanol and immiscible in water, therefore formal testing was not possible. The partition coefficient was estimated using a QSAR model (KOWWIN v1.68) based on EC Test A.8 and OECD Test Guideline 107.

The result of testing is summarised below:

Partition coefficient octanol-water (Log Kow): 0.85 (Estimated).

Description of key information

Log Kow: 0.85 (Estimated)

Key value for chemical safety assessment

Log Kow (Log Pow):
0.85

Additional information

The test material was found to be fully miscible n-octanol and immiscible in water, therefore formal testing was not possible. The partition coefficient was estimated using a QSAR model (KOWWIN v1.68) based on EC Test A.8 and OECD Test Guideline 107.

The result of testing is summarised below:

Partition coefficient octanol-water (Log Kow): 0.85 (Estimated).