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Short-term toxicity to aquatic invertebrates

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Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Study period:
December 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Qualifier:
according to
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
GLP compliance:
not specified
Test organisms (species):
Daphnia magna
Test type:
static
Water media type:
freshwater
Total exposure duration:
48 h
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
173.78 mg/L
Nominal / measured:
estimated
Conc. based on:
not specified
Basis for effect:
mobility

The estimated value forEthyl Ethoxycarbonylmethyl 2-methylidenepropanedioateafter applying the ProtoQSAR model for acute aquatic toxicity in daphnia was 173.78 mg/L. Furthermore, the compound falls inside the applicability domain of the model.

Validity criteria fulfilled:
not specified
Conclusions:
PQSAR model for acute aquatic toxicity in daphnia estimated for Ethyl Ethoxycarbonylmethyl 2-methylidenepropanedioate an acute 48h EC50 to daphnia of 173.78 mg/L. The prediction, falls inside the applicability domain of the model and is considered reliable. Furthermore, and based on the Globally Harmonized System of Classification and Labelling (CLP/GHS) , the test compound is considerd non-toxic / non-harmful. 173.78 mg/L > 100.
Executive summary:

Regulatory purpose: This study was designed to generate estimated in silico (nontesting) data for acute aquatic toxicity in daphnia forEthyl Ethoxycarbonylmethyl 2-methylidenepropanedioateto be used in the regulatory framework of REACH. EC50 = 173.78 mg/L

On the basis of EC 50 value it is concluded that this test chemical is considered to be not classified according to CLP classification criteria.

Description of key information

The acute aquatic toxicity in daphnia (EC50; 48 hours) (OECD 201) of Ethyl Ethoxycarbonylmethyl 2-methylidenepropanedioate was estimated using the PQSAR QSAR model. The estimated value was 173.78 mg/L. The prediction, falls inside the applicability domain of the model and is considered reliable. Furthermore, and based on the Globally Harmonized System of Classification and Labelling (CLP/GHS) , the test compound is considerd non-toxic / non-harmful. 173.78mg/L > 100. On the basis of EC 50 value it is concluded that this test chemical is considered to be not classified according to CLP classification criteria.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
173.78 mg/L

Additional information