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EC number: 609-691-9 | CAS number: 39464-70-5
In an acute oral toxicity study in rats conducted according to OECD 423, the target substance Ethoxylated phenol phosphate showed no mortality at the limit dose of 2000 mg/kg bw. Hence, the LD50 value was considered to exceed 2000 mg/kg bw.
In an acute oral toxicity study (acute toxic class method, OECD 423), two groups of fasted, 12 weeks old, female Wistar rats (3 rats/group) were given a single oral dose of the test item (100% purity) in water at the limit dose of 2000 mg/kg bw and were observed for 14 days. All animals survived until the end of the study showing only mild signs of toxicity. The clinical findings in the animals treated with the test item at a dose of 2000 mg/kg bw were reduced spontaneous activity, hunched back, incoordination and piloerection. All symptoms were no longer detectable by day 2 after dosing.
Throughout the 14-day observation period, the body weight gain of the test animals was within the normal range of variation for this strain. At necropsy, no macroscopic findings were observed in any animal of any step. Based on the results from this study, the oral LD50 in rats is considered to exceed 2000 mg/kg bw.
Based on the available data, Ethoxylated phenol phosphate does not warrant classification for acute toxicity. The LD50 value for the oral route was above the limit value for classification (2000 mg/kg bw).
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