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EC number: 247-873-6
CAS number: 26650-05-5
In a repeated dermal dose toxicity study in rabbits
dose levels of 0.357, 0.714 and 1.428 mL/kg SBU 185 (50 % aqueous
solution) were applied in two animals per dose group on an area of
approximately 10% of the total body surface (back). One animal's
skin remained intact, the other animal's skin was abraded.
Readings of the skin reactions were done daily during the period
of the 20 applications. The skin reactions were evaluated
comparable to Draize. Furthermore, the animals were observed for a
two-week period, following final exposures. During the test and
the observation period body weights, food consumption, and
behavior were checked daily. Urine was checked at the beginning
and at the end of the total test for the presence of protein,
reducing substances, blood pigments or any abnormality in gross
appearance. Also observations for changes in blood morphology were
made. Microscopic examinations were made of the tissues of 1
animal each of the group with the lowest and highest dose level.
The skin reactions observed show that SBU 185 (50 %
aqueous solution) caused a mild to moderate irritation with
erythema scores 0.1 to 3 but no edema at all dose levels.
No dose related effects on body weight gain and
food consumption were observed.
The urine and blood data showed no significant
deviations from the norms, respectively between the initial and
Neither the macroscopical nor the microscopical
histopathological examination of the tissues of 1 animal each of
the group with the lowest and highest dose level revealed any
serious damage. The treated skin of the animal treated with 1.428
mL SBU 185 (50 % aqueous solution)/kg bw showed slight
hyperkeratosis and slight chronical inflammation in the stratum
Solid content of SBU 185 according to producers
information: minimum 49 %. Taking this value into account, solid
content of the 50 % test solution was 24.5 % in minimum.
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