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EC number: 247-873-6
CAS number: 26650-05-5
48 -h EC50 with Daphnia magna: 19.0 mg/L
the Klimisch 1 GLP study from Kimmel (2013) the acute toxicity of item
Butanedioic acid, 2(or 3)-sulfo-, 4-[2-[(1-oxo(C12-C18(even numbered)
and C18unsaturated)alkyl))amino]ethyl]esters, disodium salts on Daphnia
magna was determined in an 48 hour static test according to OECD 202 and
EU method C.2. The test was performed with concentrations of 6.25, 12.5,
25, 50 and 100 mg test item/L(referring to 2.6, 5.2, 10.4, 20.8 and 41.5
mg solid content/L) and a blank control. Four replicates with 5 daphnids
each were set up. After 48 hours 0, 0, 0. 0, 65 and 100 % immobilization
was observed in the control and at test concentrations of 2.6, 5.2,
10.4, 20.8 and 41.5 mg solid content/L, respectively. Analytical
measurements confirmed that the test solutions were correctly dosed and
stable throughout the exposure period. Therefore the data were evaluated
based on nominal concentrations. The EC50 is 19 mg solid content/L, the
NOEC is 10.4 mg solid content/L.
Based on a bridging study it was shown that
the target substance has a significantly lower toxicity to algae when
compared to the source substance. Both substances differ only in the
length of the C-chain. Therefore, read across without further assessment
factors is considered robust and conservative. Further evidence is
provided in the read across document.
results are considered relevant and reliable for the risk assessment.
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