Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
other: Expert assessment
Adequacy of study:
key study
Study period:
August 11, 2017
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Assessment based on the outcome of a short-term repeated-dose toxicity study performed on the substance via the oral route.

Data source

Reference
Reference Type:
other: Expert assessment
Title:
Unnamed
Year:
2017
Report Date:
2017

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Assessment based on the outcome of a short-term repeated-dose toxicity study performed on the substance via the oral route.
GLP compliance:
no
Test type:
other: Assessment based on the outcome of a short-term repeated-dose toxicity study performed on the substance via the oral route.
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Sex:
male/female

Results and discussion

Effect levels
Key result
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
other: weight of evidence

Any other information on results incl. tables

see attached report.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
1-[(2-hydroxyethyl)thio]propan-2-ol is expected to have a low acute oral toxicity with an LD50 > 2000 mg/kg.
Executive summary:

An assessment was performed based on the outcome of a short-term repeated-dose toxicity study performed on the substance via the oral route to determine the acute oral toxicity of the registered substance. As a conclusion 1-[(2-hydroxyethyl)thio]propan-2-ol is expected to have a low acute oral toxicity with an LD50 > 2000 mg/kg. The substance did not meet the criteria for classification according to Regulation (EC) No.1272/2008.