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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer reviwed journal

Data source

Reference
Reference Type:
publication
Title:
Monographs on Fragrance Raw Materials-ANISIC ALDEHYDE
Author:
D. L. J. Opdyke
Year:
1979
Bibliographic source:
Food and Cosmetics Toxicology, Pages 100–101, 1979.

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Skin irritation study of p-Anisaldehyde (CAS No: 123-11-5) was conducted on intact and abraded skin of rabbits to determine the degree of skin irritancy caused by the chemical under occlusive condition.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report): Anisic aldehyde/ p-Anisaldehyde
- Molecular formula: C8H8O2
- Molecular weight: 136.1492 g/mol
- Substance type: organic
- Physical state: liquid
-Smiles: COc1ccc(C=O)cc1
-InChI: 1S/C8H8O2/c1-10-8-4-2-7(6-9)3-5-8/h2-6H,1H3
Specific details on test material used for the study:
- Name of test material (as cited in study report): Anisic aldehyde/ p-Anisaldehyde
- Molecular formula: C8H8O2
- Molecular weight: 136.1492 g/mol
- Substance type: organic
- Physical state: liquid
-Smiles: COc1ccc(C=O)cc1
-InChI: 1S/C8H8O2/c1-10-8-4-2-7(6-9)3-5-8/h2-6H,1H3

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals and environmental conditions:
No Data Available

Test system

Type of coverage:
occlusive
Preparation of test site:
other: Intact and abraded
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
100%
Duration of treatment / exposure:
24 hours
Observation period:
24 hours
Number of animals:
No Data Available
Details on study design:
No Data Available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24 h
Reversibility:
not specified
Remarks on result:
positive indication of irritation
Irritant / corrosive response data:
Mild signs of skin irritation were observed.

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria
Conclusions:
The test material p-Anisaldehyde (CAS No: 123-11-5) was considered to be mildly irritating to the intact and abraded skin of rabbits.

Executive summary:

Skin irritation study of p-Anisaldehyde (CAS No: 123-11-5) was conducted on rabbits to determine the degree of skin irritancy.

 

Each rabbit received neatp-Anisaldehyde on intact and abraded skin for 24 hours under occlusive condition and later observed for skin lesions.

 

Since the treated rabbits showed mild signs of irritation, the chemicalp-Anisaldehyde (CAS No: 123-11-5)was considered to be mildly irritating to the intact and abraded skin of rabbits.