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Diss Factsheets
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EC number: 205-771-9 | CAS number: 150-78-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Not enough details of experimental procedure for an evaluation of the study.
Data source
Reference
- Reference Type:
- publication
- Title:
- Short-term toxicity tests on the mono and di methyl ethers of hydroquinone
- Author:
- Hodge HC, Sterner JH, Maynard EA, Thomas J.
- Year:
- 1 949
- Bibliographic source:
- J. Ind. Hyg. Toxicol. 31, 79-92.
Materials and methods
- Principles of method if other than guideline:
- Subacute toxicity by oral feed
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 1,4-dimethoxybenzene
- EC Number:
- 205-771-9
- EC Name:
- 1,4-dimethoxybenzene
- Cas Number:
- 150-78-7
- Molecular formula:
- C8H10O2
- IUPAC Name:
- 1,4-dimethoxybenzene
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- DIET PREPARATION
- Rate of preparation of diet: no data
- Type of food: fox chow
- Storage of food : no data - Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- no data
- Duration of treatment / exposure:
- 5 weeks
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0; 0.5; 2 and 10%
Basis:
nominal in diet
- No. of animals per sex per dose:
- 10 males and 10 females per group were used
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- no data
- Positive control:
- no data
Examinations
- Observations and examinations performed and frequency:
- BODY WEIGHT: Yes
- Time schedule for examinations: 1 time a week, so 6 times during study (week 0 to 4).
ORGAN WEIGHT: yes (Heart, lungs, spleen, liver, kidneys, brain, stomach, testes)
MORTALITY: Yes
- Time schedule for examinations: no data
FOOD CONSUMPTION: No data
WATER CONSUMPTION: No data
CLINICAL SIGNS: Yes
- Time schedule for examinations: no data
FUNCTIONAL OBSERVATIONS: No data
OPHTHALMOSCOPIC EXAMINATION: No
HAEMATOLOGY: Yes
Time schedule for collection of blood: on 2 to 3 selected rats: 2 days prior the start of experiment, days 15-16 after beginning of experiment and days 29-30 after beginning of experiment.
Anaesthetic used for blood collection: No data
Animals fasted: No data
How many animals: 2 or 3
Parameters: haemoglobin, red blood cell counts, white blood cell counts, differential counts, description of the red cell characteristics.
CLINICAL CHEMISTRY: No data - Sacrifice and pathology:
- GROSS PATHOLOGY: No data
HISTOPATHOLOGY: yes
AUTOPSY: tissues sections of organs weighted and also small and large intestine were taken and observed.
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- no effects observed
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- effects observed, treatment-related
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- no effects observed
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- effects observed, treatment-related
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Histopathological findings: neoplastic:
- effects observed, treatment-related
- Details on results:
- 0.5% of PDMB produced no depression in growth in both male and female rats, but a stimulation to growth which amounted to about 10 g for males.
2% of paradimethoxybenzene caused a small but apparent diminution of growth; this amounted to 18 g in the male rats and 8 g in the female. The inclusion of 10% of paradimethoxybenzene was followed by almost complete inhibition of growth.
The animals lost weight somewhat during the early period, but had approximately regained their initial weight at the end of the experiment. Male and female weighed less than the control group (94 g for males, 51 g for females).
There was no mortality in any of the groups.
The hemoglobin values ranged between 12.2 and 18.7 g; most of the values fell around 14 to 16. Red blood cell counts ranged from 5.2 to 6.7 millions, which are normal values. The white blood cell counts were mostly 6 to 12 thousand, although an occasional value of 15-20 thousand was encountered. Scattered high counts like this are not uncommon. The differential counts appear to be normal; in most cases there were 70-80% lymphocytes.
No organ weight changes which could not adequately be explained on the basis of depression of general body growth.
At necropsy:
- one rat fed at 0.5% PDMB had congestion in the lung.
- one rat fed at 2% PDMB had hemorragic testes.
- in the rat fed at 10%, the organs appeared smaller than normal. In 2 rats, kidneys were smaller and darkened and in 2 others brownishgray streaks were observed on liver capsule. One rat had a reddened gastric mucosa and another a hemorragic lung.
Microscopically, the lungs exhibited round cells collected about the blood vessels in some rats in all groups.
The absence of signs of irritation in the gastrointestinal tract, and especially the absence of toxic changes in the liver and kidneys, are noteworthy.
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 2 other: %
- Sex:
- male/female
- Dose descriptor:
- NOEL
- Effect level:
- 0.5 other: %
- Sex:
- male/female
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
It is quite possible that there is sufficient odor and flavor connected with large percentage addition of this ether to the diets to decrease the palatability
of the ration and possibly reduce the total food intake.
Hematological studies in general gave normal values. Urine analyses were normal. Organ weights studies did not reveal evidence of specific toxic
effects. There were no significant histological changes which could be attributed to the inclusion of paradimethoxybenzene.
Applicant's summary and conclusion
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