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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: No enough details. Documentation is insufficient for assessment.

Data source

Reference
Reference Type:
publication
Title:
Short-term toxicity tests on the mono and di methyl ethers of hydroquinone
Author:
Hodge HC, Sterner JH, Maynard EA, Thomas J.
Year:
1949
Bibliographic source:
J. Ind. Hyg. Toxicol. 31, 79-92.

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
acute toxicity by i.p. route
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
no data

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified
Details on exposure:
- Doses / concentrations:
Groups of 10 to 22 mice were given doses of paradimethoxybenzene ranging from 30 to 80 mg per animal, as follow:
- 10 animals in group treated with 30 mg (average body weight was 29 gm). Dose: 1034 mg/kg
- 10 animals in group treated with 35 mg (average body weight was 29 gm). Dose: 1207 mg/kg
- 22 animals in group treated with 40 mg (average body weight was 27 gm). Dose: 1481 mg/kg
- 20 animals in group treated with 50 mg (average body weight was 27 gm). Dose: 1852 mg/kg
- 10 animals in group treated with 60 mg (average body weight was 25 gm). Dose: 2400 mg/kg
- 10 animals in group treated with 70 mg (average body weight was 27 gm). Dose: 2592 mg/kg
- 12 animals in group treated with 80 mg (average body weight was 25 gm). Dose: 3200 mg/kg
Doses:
30; 35; 40; 50; 60; 70; 80 mg/animal corresponding to 1034; 1207; 1481; 1852; 2400; 2592; 3200 mg/kg bw.
No. of animals per sex per dose:
10 to 22 animals per dose group, sex unspecified
Control animals:
not specified
Details on study design:
no data
Statistics:
no data

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 100 mg/kg bw
Mortality:
The 30 mg dose killed 30%,
the 35 mg dose killed 70%,
the 40 mg dose killed 73%,
the 50 and 60 mg dose killed 80%,
the 70 and 80 mg dose killed 100% of the treated animals.
Clinical signs:
Mice given paradimethoxybenzene intraperitoneally developed a wobbly gait immediately following injection. This was followed in a few minutes by paralysis of the hind quarters, accompanied by spasms perhaps of anoxial origin. At the higher doses, mice appeared to be in a narcosis about 15 minutes after injection. Some mice still exhibited degrees of anesthesia as long as 18 hours after injection.
Body weight:
no data
Gross pathology:
no data
Other findings:
no data

Applicant's summary and conclusion