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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1981-07-14 to 1981-07-29
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1982
Report date:
1982

Materials and methods

Principles of method if other than guideline:
according to BASF-internal standard
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-(1,1-dimethylethyl)cyclohexyl acrylate
EC Number:
282-104-8
EC Name:
4-(1,1-dimethylethyl)cyclohexyl acrylate
Cas Number:
84100-23-2
Molecular formula:
C13H22O2
IUPAC Name:
4-tert-butylcyclohexyl prop-2-enoate
Details on test material:
- Name of the test substance (as cited in study report): 4-tertiaer-Butylcyclohexylacrylat
- Substance type: organic
- Physical state: liquid

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Charles River WIGA, Sulzfeld, FRG
- Age at study initiation: about 12 weeks
- Weight at study initiation: males: 200-230 g; females: 180-190 g
- Fasting period before study: yes, 16 hours
- Housing: 5 animals per cage (DK-III stainless steel wire mesh cages)
- Diet: ad libitum SSNIFF R (Ssniff Versuchstierdiäten, Soest, FRG)
- Water: ad libitum (fully demineralized water each workday and tap water on public holidays)
- Acclimation period: at least one week

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 26
- Humidity (%): 45 - 75
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
olive oil
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 43 % w/v (2150 mg/kg); 50 % w/v (5000 mg/kg)
- Amount of vehicle: 5 and 10 mL/kg
- Justification for choice of vehicle: Test substance not soluble in water.

MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg
Doses:
2150 and 5000 mg/kg
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations: weighing was conducted on study days 1, 2, 3, 7 and 13; Recording of signs and symptoms < 15 min, 15 min, 30 min , 1 h, 2 h, 4 h, and 5 h after administration of test substance and then once each workday
- Necropsy of survivors performed: yes
- examinations performed: clinical signs, body weight

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
approximate LD50
Effect level:
ca. 5 000 mg/kg bw
Based on:
test mat.
Mortality:
No deaths were observed at 2150 mg/kg bw. At 5000 mg/kg bw 4 animals died during the course of the study.
Clinical signs:
other: At 2150 mg/kg bw both male and females rats showed a poor general state during the first two days. Dyspnea, apathy, staggering and piloerection lasted up to study day 3. At 5000 mg/kg bw a poor general state was observed in males during the first two days
Gross pathology:
Animals that died during the study showed acute dilatation of the atria, acute congestion and lung emphysema. Sacrificed animals did not show any gross internal lesions.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met