Registration Dossier
Registration Dossier
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EC number: 282-104-8 | CAS number: 84100-23-2
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
The calculated half-lifes at pH 8 and pH 7 of the test substance are 3.609 and 36.090 years, respectively (QSAR, HYDROWIN v.2.00).
Key value for chemical safety assessment
Additional information
QSAR-disclaimer
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met. Furthermore according to Article 25 of the same Regulation testing on vertebrate animals shall be undertaken only as a last resort.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment of 4-tert-butylcyclohexyl acrylate (Q)SAR results were used for hydrolysis. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.
Therefore, further experimental studies on hydrolysis are not provided.
The half-life of the test substance was calculated using EPI Suite HYDROWIN program. The calculation revealed a half-life of 3.609 years at pH 8 and a half-life of 36.090 years at pH 7 for the test substance. Thus, in contact with water the substance will hydrolyse slowly at pH 7. At pH 8 the substance will hydrolyse rapidly.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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