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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from peer reviewed journals

Data source

Reference
Reference Type:
publication
Title:
Monographs on Fragrance Raw Materials: Diethyl malonate
Author:
D. L. J. Opdyke
Year:
1976
Bibliographic source:
Food and Cosmetics Toxicology, Volume 14, Supplement, 1976, Pages 745-746

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To assess the skin irritation potential of diethyl malonate in humans
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
Name of the test chemical: 1,3-diethyl propanedioate
Common Name: diethyl malonate
Molecular Fiormula:C7H12O4
Molecular Weight:160.1678 g/mol
InChI : 1S/C7H12O4/c1-3-10-6(8)5-7(9)11-4-2/h3-5H2,1-2H3
Substance Type: Organic
Physical State: Liquid
Specific details on test material used for the study:
Name of the test chemical: 1,3-diethyl propanedioate
Common Name: diethyl malonate
Molecular Fiormula:C7H12O4
Molecular Weight:160.1678 g/mol
InChI : 1S/C7H12O4/c1-3-10-6(8)5-7(9)11-4-2/h3-5H2,1-2H3
Substance Type: Organic
Physical State: Liquid

Test animals

Species:
other: humans
Strain:
not specified
Details on test animals and environmental conditions:
no data available

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
other: petrolatum
Controls:
not specified
Amount / concentration applied:
4% in petrolatum
Duration of treatment / exposure:
48 hours
Observation period:
48 hours
Number of animals:
no data available
Details on study design:
no data available

Results and discussion

In vitro

Other effects / acceptance of results:
no data available

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
48 h
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No irritation observed

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:

Diethyl malonate was not irritating to human skin after 48 hours exposure.
Executive summary:

A skin irritation study was performed in humans to assess the irritation potential of Diethyl malonate. Diethyl malonate was tested 4% in petrolatum in 48 hours closed patch test on human volunteers.Diethyl malonate was not irritating to human skin after 48 hours exposure.