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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from authoritative databases

Data source

Reference
Reference Type:
other: Authoritative database
Title:
HSDB for the CAS: 111-55-7
Author:
U.S National Library of Medicine
Year:
2003
Bibliographic source:
Hazardous Substance Databank (HSDB), U.S National Library of Medicine, last updated 2003

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To assess the ocular irritation potential of ethylene glycol diacetate in rabbits
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
Name of the test chemical: 2-(acetyloxy)ethyl acetate
Common Name: Ethylene glycol diacetate
Molecular Formula: C6H10O4
Molecular Weight: 146.141 g/mol
Substance Type: Organic
Physical State: Liquid
Specific details on test material used for the study:
Name of the test chemical: 2-(acetyloxy)ethyl acetate
Common Name: Ethylene glycol diacetate
Molecular Formula: C6H10O4
Molecular Weight: 146.141 g/mol
Substance Type: Organic
Physical State: Liquid

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
no dat available

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
no data available
Duration of treatment / exposure:
24 hours
Observation period (in vivo):
24 hours
Duration of post- treatment incubation (in vitro):
no data available
Number of animals or in vitro replicates:
no data available
Details on study design:
TEST SITE
- Area of exposure: eyes
SCORING SYSTEM:
The degree of eye injury was rated on a scale of 1 to 10. Most severe injuries were rated 10

Results and discussion

Other effects / acceptance of results:
no data available
Results of in vivo study
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24 h
Score:
1
Max. score:
10
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
Ethylene glycol acetate was rated Grade 1.

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
Primary Irritation score after 24 hours for Ethylene glycol acetate was Grade 1.Most severe injuries were rated 10.
Based on the ratings, ethylene glycol acetate can be considered not irritating to rabbit eyes.
Executive summary:

The eye irritation potential of ethylene glycol acetate was assessed in rabbits.

Ethylene glycol acetate was instilled into rabbit eyes and observed for signs of irritation till 24 hours.The degree of eye injury observed after 24 hours was rated on a scale of 1 to 10. Most severe injuries were rated 10.Primary Irritation score after 24 hours forEthylene glycol acetate was Grade 1.

Based on the ratings, ethylene glycol acetate can be considered not irritating to rabbit eyes.