Registration Dossier
Registration Dossier
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EC number: 248-196-9 | CAS number: 27059-08-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data from secondary source
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Acute oral toxicity study in Rat for CAS no: 111-55-7
- Author:
- U.S .National library of medicine
- Year:
- 2 017
- Bibliographic source:
- ChemID plus A TOXNET DATABASE.2017
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity study of Ethylene Glycol Diacetate was performed in Rat
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- yes
Test material
- Reference substance name:
- Ethylene di(acetate)
- EC Number:
- 203-881-1
- EC Name:
- Ethylene di(acetate)
- Cas Number:
- 111-55-7
- Molecular formula:
- C6H10O4
- IUPAC Name:
- 2-(acetyloxy)ethyl acetate
- Details on test material:
- - Name of test material (as cited in study report):Ethylene Glycol Diacetate
- Molecular formula :C6H10O4
- Molecular weight ):146.141g/mole
- Substance type:organic
- Physical state:solid
- Purity:No data available
- Impurities (identity and concentrations):No data available
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):Ethylene Glycol Diacetate
- Molecular formula :C6H10O4
- Molecular weight ):146.141g/mole
- Substance type:organic
- Physical state:solid
- Purity:No data available
- Impurities (identity and concentrations):No data available
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 6865mg/kg bw
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 6 865 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 50% mortality was observed
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- LD50 was considered to be 6865mg/kg body weight.When rats were treated with Ethylene Glycol Diacetate (111-55-7) orally.
- Executive summary:
Acute oral toxicity study was done in rat using Ethylene Glycol Diacetate (111-55-7).50% mortality was observed at dose 6865 mg/kg bw. Hence LD50 was considered to be 6865mg/kg body weight.
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