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Environmental fate & pathways

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Biodegradation in water:

Biodegradability of test chemical 2,2'-[(3-acetamidophenyl)imino]diethyl diacetate ( CAS no. 27059 -08 -1) is predicted using OECD QSAR tool box v.3.3using log Kow as a primary descriptor. The test chemical 2,2'-[(3-acetamidophenyl)imino]diethyl diacetate showed 1.21 % biodegradation in 28 days by considering BOD as parameterand microorganisms as inoculum. As the percent biodegradation is very less it is concluded that this chemical is not readily biodegradable.

Biodegradation in water and sediments:

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 2,2'-[(3-acetamidophenyl)imino]diethyl diacetate (CAS No: 27059 -08 -1). If released in to the environment, 31.6 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of the chemical 2,2'-[(3- acetamidophenyl)imino]diethyl diacetate in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is low whereas the half-life period of 2,2'-[(3-acetamidophenyl)imino]diethyl diacetate in sediment is estimated to be 337.5 days (8100 hrs).  However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.083 %), indicates that test chemical 2,2'-[(3-acetamidophenyl)imino]diethyl diacetate is not persistent in sediment..

Biodegradation in soil:

The half-life period of2,2'-[(3-acetamidophenyl)imino]diethyl diacetate(CAS No: 27059 -08 -1) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 68.3% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical2,2'-[(3-acetamidophenyl)imino]diethyl diacetatein soil is estimated to be 75 days (1800 hrs). Based on this half-life value of test chemical2,2'-[(3-acetamidophenyl)imino]diethyl diacetate, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.

Additional information

Biodegradation in water:

Predicted data for target compound 2,2'-[(3-acetamidophenyl)imino]diethyl diacetate ( CAS no. 27059 -08 -1)and supporting weight of evidence studies for its closest read across chemicals with log Kow as a primary descriptor were reviewed for the biodegradation endpoint which are summarized as below.

 

Biodegradability of test chemical 2,2'-[(3-acetamidophenyl)imino]diethyl diacetate ( CAS no. 27059 -08 -1) is predicted using OECD QSAR tool box v.3.3using log Kow as a primary descriptor. The test chemical 2,2'-[(3-acetamidophenyl)imino]diethyl diacetate showed 1.21 % biodegradation in 28 days by considering BOD as parameterand microorganisms as inoculum. As the percent biodegradation is very less it is concluded that this chemical is not readily biodegradable.

 

In another prediction done using Estimation Programs Interface Suite (EPI suite, 2017) the biodegradation potential of the test chemical 2,2'-[(3-acetamidophenyl)imino]diethyl diacetate (CAS No: 27059 -08 -1) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical  2,2'-[(3-acetamidophenyl)imino]diethyl diacetate is expected to be not readily biodegradable.

 

In a supporting weight of evidence study from seconadary source ( J checK) for read across chemical 5-tert-butyl-2-[4-[2-[5-tert-butylbenzoxazol-2-yl]vinyl]phenyl]benzoxazole (CAS no. 1552-47-2). The Biodegradability test was carried out for 28 days, activated sludge was taken as inoculum, concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l. The percentage degradation of read across substance 5-tert-butyl-2-[4-[2-[5-tert-butylbenzoxazol-2-yl]vinyl]phenyl]benzoxazole was determined to be 1 % degradation by BOD, 0 % degradation by HPLC parameter in 28 days. Thus, based on percentage degradation, 5-tert-butyl-2-[4-[2-[5-tert-butylbenzoxazol-2-yl]vinyl]phenyl]benzoxazole is considered to be not readily biodegradable in water.

 

In another supporting weight of evidence study from seconadary source (J checK) for read across substance 3-(dimethylamino)benzoic acid (CAS no. 99-64-9). The Biodegradability test was carried out for 28 days, activated sludge was taken as inoculum and concentration of inoculum i. e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l. The percentage degradation of test substance was determined to be 0% degradation by BOD and 1% degradation by TOC removal and HPLC parameter in 28 days. These values of percentages very less, so test chemical 3-(dimethylamino)benzoic acid is considered to be not readily biodegradable.

 

On the basis of above results for target chemical 2,2'-[(3-acetamidophenyl)imino]diethyl diacetate ( CAS no. 27059 -08 -1)from ( EPI suite 2017 and OECD QSAR tool box v3.3 2017) and for its read across substances ( from secondary source) the target chemical 2,2'-[(3-acetamidophenyl)imino]diethyl diacetate ( CAS no. 27059 -08 -1)can be expected to be not readily biodegradable.

Biodegradation in water and sediments:

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 2,2'-[(3-acetamidophenyl)imino]diethyl diacetate (CAS No: 27059 -08 -1). If released in to the environment, 31.6 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of the chemical 2,2'-[(3- acetamidophenyl)imino]diethyl diacetate in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is low whereas the half-life period of 2,2'-[(3-acetamidophenyl)imino]diethyl diacetate in sediment is estimated to be 337.5 days (8100 hrs).  However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.083 %), indicates that test chemical 2,2'-[(3-acetamidophenyl)imino]diethyl diacetate is not persistent in sediment.

Biodegradation in soil:

The half-life period of2,2'-[(3-acetamidophenyl)imino]diethyl diacetate(CAS No: 27059 -08 -1) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 68.3% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical2,2'-[(3-acetamidophenyl)imino]diethyl diacetatein soil is estimated to be 75 days (1800 hrs). Based on this half-life value of test chemical2,2'-[(3-acetamidophenyl)imino]diethyl diacetate, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.