Registration Dossier
Registration Dossier
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EC number: 473-780-7 | CAS number: -
Endpoint summary
Administrative data
Description of key information
The acute oral and dermal toxicity of NX 8000J is low. The LD50 is >2000 mg/kg bw, for both oral and dermal exposure.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
In accordance with column 2 of REACH Annex VII, the acute toxicity by inhalation does not need to be determined as exposure of humans via inhalation is unlikely.
The acute oral toxicity was determined in a study according to OECD guideline 425 (up-an-down procedure). In this study female rats were exposed to either 175, 550 or 2000 mg/kg bw NX 8000J. There were no deaths, no clinical signs and no macroscopic abnormalities.
The acute dermal toxicity was determined in a study according to OECD guideline 402 (acute dermal toxicity). In this study male and female rats were exposed to 2000 mg/kg bw NX 8000J. There were no deaths, no clinical signs or signs of irritation and no macroscopic abnormalities.
Justification for classification or non-classification
Based on the LD50of > 2000 mg/kg bw in rats for both oral and dermal expsoure, and the absence of other major significant effects, NX 8000J does not need to be classified for acute toxicity according to EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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