Registration Dossier
Registration Dossier
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EC number: 473-780-7 | CAS number: -
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
The substance is a complex organic molecule that includes 4-propylbenzyl moieties, a nonane backbone, multiple saturated, fused 6-member rings containing two oxygen atoms and a glycol moiety. It has a molecular weight of 483. It is a solid at room temperature that is almost insoluble in water (solubility 1.5 µg/L) and has ca 80% of the particles >100µM. The melting point is 237ºC and the substance has essentially a negligible vapour pressure (3.9 x 10-11Pa). The log Pow is 5.71. The substance is essentially non-toxic, although minor pathological changes, not considered of toxicological significance, were evident in kidney, spleen and bone marrow at the highest dose examined (ca 1682 m/g bw/d) in a 90 day study in which the substance was administered in the diet.
Absorption
Given the particle size and negligible vapour pressure the substance is unlikely to be inhaled.
The substance is insoluble in water, but extremely soluble in lipids. Thus it is unlikely to be absorbed orally by conventional passive diffusion. However, there is some evidence of systemic effects at very high dose levels when the substance is administered in the diet. This might be a result of dissolution into dietary lipid emulsions and absorbed through the facilitated diffusion mechanism by which dietary fats are absorbed or it might be due to absorption of an impurity. Therefore, as no experimental data are present, 50% oral absorption is used as a worst case.
The dermal absorption is estimated to be not more than 10%, given the MW of approx. 500 and the logP of 5.7.
Distribution
If absorbed, the substance is likely to bioaccumulate in fatty tissues.
Metabolism
If absorbed, metabolism by oxidation of the side chains of the 4-propylbenzyl moieties and conjugation of the hydroxyl groups of the C9 backbone of the molecule are possible.
Another possibility is hydrolysis to 4-propylbenzoic acid and nonan-1,2,3,4,5,6-hexol.
Excretion
Given the molecular weight and lipid solubility of the molecule, if absorbed, it is likely to be excreted in bile in rats, although it may appear in human urine. If the molecule hydrolyses, the products are likely to appear in urine.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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