Registration Dossier

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2000
Report Date:
2000

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
Deviations:
no
Test type:
acute toxic class method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.

Any other information on results incl. tables

Table 7.2.1/2: Individual and group mean bodyweights (g) in treated animals during the observation period

Dose mg/kg

Animal n° and sex

Bodyweight (g) at

Day 1 *

Day 8

A

Day 15

B

2000

3F

98

137

(39)

158

(21)

4F

98

135

(37)

153

(18)

5F

97

138

(41)

163

(25)

Mean

98

137

(39)

158

(21)

6M

107

147

(40)

198

(51)

7M

105

151

(46)

197

(46)

8M

106

168

(62)

214

(46)

Mean

106

155

(49)

203

(48)

*: Prior to dosis

Bodyweight gain shown in parenthesis

A: Weight gain on Day 8 B: Weight gain on Day 15

Applicant's summary and conclusion