Registration Dossier

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Cross-reference
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2001
Report Date:
2001

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
no
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
nose only

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 4.06 mg/L air
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other: maximum practicable concentration

Any other information on results incl. tables

Table 7.2.2/1: Body weights - individual and group mean values (g)

Group

Rat

Day of observation

-6

-3

0

7

14

1M

(control)

1

213

241

263

322

351

2

213

240

257

304

330

3

225

258

281

333

356

4

224

254

277

325

367

5

215

249

271

318

355

Mean

218

248

270

320

352

2M

(treated)

11

213

244

272

310

343

12

221

248

264

298

328

13

212

244

265

308

346

14

216

240

266

294

323

15

216

239

259

291

316

Mean

216

243

265

300

331

1F

(control)

6

200

217

227

325

247

7

201

206

218

225

241

8

199

210

212

225

239

9

203

216

215

231

251

10

209

222

231

240

262

Mean

202

214

221

231

248

2F

(treated)

16

205

209

213

219

224

17

204

219

223

230

252

18

202

206

217

229

242

19

203

210

231

235

241

20

204

214

217

218

231

Mean

204

212

220

226

238

 

Applicant's summary and conclusion