Registration Dossier
Registration Dossier
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EC number: 248-451-4 | CAS number: 27425-55-4
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Bericht ueber die gewerbetoxikologische Grundprüfung
- Author:
- BASF AG
- Year:
- 1 979
- Bibliographic source:
- BASF AG, Abteilung Gewerbehygiene und Toxikologie: (1979)
- Reference Type:
- other: Authoritative data base
- Title:
- GCID: 512735
- Author:
- ACToR database
- Year:
- 2 011
- Bibliographic source:
- ACToR (Aggregated Computational Toxicology Resource):- BASF AG, Abteilung Gewerbehygiene und Toxikologie: Bericht ueber die gewerbetoxikologische Grundprüfung (1979)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- The test substance was applied at a dose of 50 mg/animal and the animals were observed for a period of 8 days.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- N,N-diethylaniline
- EC Number:
- 202-088-8
- EC Name:
- N,N-diethylaniline
- Cas Number:
- 91-66-7
- IUPAC Name:
- N,N-diethylaniline
- Details on test material:
- - Name of test material: N,N-diethylaniline
- Substance type: Organic
- Physical state: Liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 50 mg
- Duration of treatment / exposure:
- no data
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- no data
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 8 days
- Reversibility:
- not specified
- Remarks on result:
- other: Dose: 50 mg/animal ; result: not irritating
- Other effects:
- Not irritating at a dose concentration of 50 mg/animal
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In the acute eye irritation study in rabbits N,N-diethylaniline showed no eye irritation at a concentration of 50mg/animal suggesting that N,N-diethylaniline was not irritating to eyes.
- Executive summary:
In the acute eye irritation study in rabbits N,N-diethylaniline showed no eye irritation at a concentration of 0.1 ml/animal suggesting that N,N-diethylaniline was not irritating to eyes.
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